Cancer is one of the deadliest diseases, causing million of deaths each year globally.Conventional anti-cancer therapies are non-targeted and have systemic toxicities limiting their versatile applications in many cancers.So, there is an unmet need for more specific therapeutic options that will be effective as well as free from toxicities.Antibody-
Two enantiomers of 2-hydroxyglutarate (2HG), L (L2HG) and D (D2HG), are metabolites of unknown function in mammalian cells that were initially associated with separate and rare inborn Mealtime errors of metabolism resulting in increased urinary excretion of 2HG linked to neurological deficits in children (Chalmers et al., 1980; Duran et al., 1980;
ABSTRACT Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin.However, the molecular basis of their Adapters action is not fully understood.Here, we examined the genomic and transcriptome responses by Enterobacter hormaechei after prolonged exposure to either CSA-13 or colistin.
This paper analyzes the challenges and opportunities brought by foreign direct investment in general and in Brazil particularly.The study is based on literature review and statistical data show that foreign direct investments have important effects on the NPG-Surcharge business environment of the host country as they bring productivity improvement,
Optimal defibrillation timing guided by ventricular fibrillation (VF) waveform analysis would contribute to improved survival of out-of-hospital cardiac arrest (OHCA) patients by minimizing myocardial damage caused by futile defibrillation shocks and minimizing interruptions to cardiopulmonary resuscitation.Recently, fuzzy entropy (FuzzyEn) tailore